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Enantioselective desymmetrization of prochiral diesters catalyzed by immobilized Rhizopus oryzae lipase

✍ Scribed by Zaida Cabrera; Jose M. Palomo


Book ID
113929602
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
344 KB
Volume
22
Category
Article
ISSN
0957-4166

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Lipase-catalyzed enantioselective desymm
✍ Shuji Akai; Toshiaki Tsujino; Tadaatsu Naka; Kouichi Tanimoto; Yasuyuki Kita πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 62 KB

Oxindoles 3b-d (91-98% ee) having a chiral quaternary carbon center at the C-3 position were prepared from readily available oxindoles 5a-c in 50-64% overall yields, in which an enantioselective desymmetrization of prochiral 1,3-diols 2b-d using a Candida rugosa lipase (Meito OF) and 1-ethoxyvinyl 2