Lipase-catalyzed enantioselective desymm
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Shuji Akai; Toshiaki Tsujino; Tadaatsu Naka; Kouichi Tanimoto; Yasuyuki Kita
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Article
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2001
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Elsevier Science
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French
β 62 KB
Oxindoles 3b-d (91-98% ee) having a chiral quaternary carbon center at the C-3 position were prepared from readily available oxindoles 5a-c in 50-64% overall yields, in which an enantioselective desymmetrization of prochiral 1,3-diols 2b-d using a Candida rugosa lipase (Meito OF) and 1-ethoxyvinyl 2