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Enantioselective Copper-Catalyzed Decarboxylative Propargylic Alkylation of Propargyl β-Ketoesters with a Chiral Ketimine P,N,N-Ligand

✍ Scribed by Zhu, Fu-Lin; Zou, Yuan; Zhang, De-Yang; Wang, Ya-Hui; Hu, Xin-Hu; Chen, Song; Xu, Jie; Hu, Xiang-Ping


Book ID
121805389
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
445 KB
Volume
53
Category
Article
ISSN
0044-8249

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Enantioselective copper-catalyzed conjug
✍ Toshiaki Morimoto; Yoichi Yamaguchi; Masato Suzuki; Akihito Saitoh 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 100 KB

New P,N ligands prepared from (S)-2-alkyl-2-aminoethylphosphines and a-substituted pyridines are efficient chiral ligands for the copper-catalyzed conjugate addition of diethylzinc to 2-cyclohexen-1-one and chalcone. The best result (90-91% ee) for the cyclohexenone was obtained with Cu(OTf) 2 (0.7-