Enantioselective conjugate addition with chiral amidocuprates

✍ Scribed by Bryant E. Rossiter; Masakatsu Eguchi

• Book ID: 104226506
• Publisher: Elsevier Science
• Year: 1990
• Tongue: French
• Weight: 269 KB
• Volume: 31
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)94404-6

✦ Synopsis

A series of chii secondary amines have been screened as non-tmnsfearable cuprate ligands for the promotion of enantiosekctivity in conjugate addition to 2cyclohexenone.

A mechanism is presented to rationalize the enantioselectivity obsaved.

Conjugate addition to enones using organocuprate reagents1 is a useful organic reaction whose utility would be extended if it were rendered enantioselective. A number of chiral organocuprates have been developed to do such, some with considerable success. 2-5 Little is known, however, about the relationship in these reactions