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Enantioselective chromatography and absolute configuration of N,N-dimethyl-3-(naphthalen-2-yl)-butan-1-amines: Potential sigma1 ligands

✍ Scribed by Simona Collina; Guya Loddo; Mariangela Urbano; Daniela Rossi; Maria Grazia Mamolo; Daniele Zampieri; Stefano Alcaro; Andrea Gallelli; Ornella Azzolina

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
358 KB
Volume
18
Category
Article
ISSN
0899-0042

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✍ J.S. Dileep Kumar; Vattoly J. Majo; Jaya Prabhakaran; Norman R. Simpson; Ronald 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 138 KB

## Abstract A convenient synthesis of [N‐methyl‐^11^C]‐3‐[(6‐dimethylamino)pyridin‐3‐yl]‐2,5‐dimethyl‐__N__,__N__‐dipropylpyrazolo[1,5‐a]pyrimidine‐7‐amine (R121920), a highly selective CRF~1~ antagonist has been developed as a potential PET ligand. 3 ‐ [(6 ‐ methylamino)pyridin ‐ 3 ‐ yl]‐2,5‐dimet