Enantioselective Biocatalytic Oxidative Desymmetrization of Substituted Pyrrolidines
✍ Scribed by Valentin Köhler; Kevin R. Bailey; Anass Znabet; James Raftery; Madeleine Helliwell; Nicholas J. Turner
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 332 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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We are grateful to GlaxoSmithKline and the EPSRC for an Industrial CASE studentship (to A.P.) and to Croda for a Dorothy Hodgkin Award (to B.Y.). We thank Dr. James Raftery for the X-ray data on 3.
The formation of enantiomerically enriched products from chiral organolithium species is a highly efficient and selective approach for organic synthesis. [1] The majority of examples involve the selective asymmetric deprotonation of a prochiral hydrogen atom adjacent to an oxygen or nitrogen atom, s