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Enantioselective behavioral effects of threo-methylphenidate in rats

✍ Scribed by David A. Eckerman; Sheryl S. Moy; Ann N. Perkins; Kennerly S. Patrick; George R. Breese


Book ID
113224270
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
652 KB
Volume
40
Category
Article
ISSN
0091-3057

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Enantioselective in vitro hydrolysis of methylphenidate (MPH) by the blood esterases of seven mammalian species is reported. The species included rats, rabbits, dogs, cattle, horses, monkeys, and humans. In vitro incubations up to 8 h were carried out in plasma, red blood cells, and whole blood of t