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Enantioselective analysis of (R)- and (S)-carvedilol in human plasma by high-performance liquid chromatography

✍ Scribed by G. Lamprecht; L. Gruber; K. Stoschitzky; W. Lindner

Publisher
Springer
Year
2002
Tongue
English
Weight
433 KB
Volume
56
Category
Article
ISSN
0009-5893

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A specific plasma level assay for the enantiomers of alpha-lipoic acid is described. It makes use of liquid-liquid extraction, chemical reduction to the dithiol enantiomers, and their precolumn chiral derivatisation with o-phthalaldehyde in the presence of D-phenylalanine. The two diastereomeric der