Enantioselective allylic substitution using a novel (phosphino-1,3-oxazine)palladium catalyst

✍ Scribed by P. Andrew Evans; Thomas A. Brandt

• Book ID: 104255947
• Publisher: Elsevier Science
• Year: 1996
• Tongue: French
• Weight: 267 KB
• Volume: 37
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(96)02162-4

✦ Synopsis

Treatment of 1,3-diphenyl-2-propenyl acetate 1 with the sodium salt of dimethyl malonate and the palladium complex of the phosphino-1,3-oxazine ligand cis3a gave the allylic substitution product2 in 99% yield and 95% enantiomeric excess.