Enantioselective Aldol Reactions Catalyzed by N-Toluenesulfonyl-L-proline Amide in Ionic Liquids.
โ Scribed by Maria Meciarova; Stefan Toma; Albrecht Berkessel; Burkhard Koch
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 26 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A concise and enantioselective synthesis of (__S__)โethyl 2โcyclopentylโ2โhydroxyโ2โarylacetate, a key intermediate for the muscarinic receptor, is reported. The tertiary stereogenic center was constructed with good stereoselectivity through the __Lโ__prolineโcatalyzed direct asymmetric