Aldol reaction of aldehydes with difluomketene ethyl trimethylsilyl acetal (1) in the presence of a substoichiometric amount of chiral Lewis acid 2 or 3 provides the corresponding ~,a-difluom hydroxy esters 4-12 with high enantioselectivitles (up to 98% ee). Reaction temperature has a great influenc
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Enantioselective aldol reaction with a bromofluoroketene silyl acetal catalyzed by a chiral Lewis acid
β Scribed by Katsuhiko Iseki; Yoshichika Kuroki; Yoshiro Kobayashi
- Book ID
- 104258026
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 138 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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