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Enantiomerically pure nucleophiles in diastereoselective palladium catalysed allylic substitution reactions

✍ Scribed by Mark E. Humphries; Barry P. Clark; Samantha Regini; Lara Acemoglu; Jonathan M.J. Williams


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
85 KB
Volume
15
Category
Article
ISSN
0899-0042

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Allyl carbonates (Z)-8 and (E)-9 are available from the converted into (S)-Ξ³-butyrolactone 13 in a three step sequence. When the same protocol is applied to the isomeric addition of the chiral alkenyllithium reagent 5b to aromatic aldehydes 6. When sujected to a palladium-catalyzed diesters 10 and 1