✦ LIBER ✦
Enantiomerically pure 1-(2-methoxy-1-naphthyl) and 1-(2-methylthio-1-naphthyl)isoquinoline: two new axially chiral NO and NS ligands for asymmetric catalysis
✍ Scribed by Giorgio Chelucci; Alessia Bacchi; Davide Fabbri; Antonio Saba; Fausta Ulgheri
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 240 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The synthesis and resolution of 1-(2-methoxy-l-naphthyl)isoquinoline and 1-(2-methylthio-1naphthyl)isoquinoline is reported. These ligands were assessed in the enantioselective palladium catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethylmalonate. Enantioselectivity up to 68 % was obtained.