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Enantiomeric Synthesis of l -(or 1‘ R ,2‘ S )-Carbocyclic Cyclopropyl Nucleosides

✍ Scribed by Lee, Mi Gyoung; Du, Jin Fa; Chun, Moon Woon; Chu, Chung K.


Book ID
120991913
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
207 KB
Volume
62
Category
Article
ISSN
0022-3263

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Enantiomeric synthesis of l- (or 1S,2R,3
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The total synthesis of L-(or IS,2R,3S,5S)-bicarbocyclic nucleosides (8-15) has been accomplished. The key intermediate 3 was synthesized in two steps from the known chiral compound 1 through a stereoselective cyclopropanation under Furukawa conditions and its X-ray structure has been determined. The

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