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Enantiomeric separations of binaphthyl derivatives by capillary electrophoresis using N-(2-hydroxydodecyl)-L-threonine as chiral selector: Effect of organic additives

✍ Scribed by Arjun Ghosh; Joykrishna Dey

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 376 KB
Volume: 29
Category: Article
ISSN: 0173-0835
DOI: 10.1002/elps.200700638

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✦ Synopsis

Abstract

The chiral selectivity of a novel amphiphile, N‐(2‐hydroxydodecyl)‐L‐threonine (2‐HDT), was evaluated for enantiomeric resolution of three binaphthyl derivatives (±)−1,1′‐bi‐2‐naphthol, (±)−1,1′‐binaphthyl‐2,2′‐diamine, and (±)−1,1′‐binaphthyl‐2,2′‐diylhdrogen phosphate (BNP) by micellar EKC. The effects of three organic modifiers, methanol, isopropanol, and acetonitrile, on the separations of enantiomers of these compounds were investigated. Separation of enantiomers could be achieved in relatively dilute solutions of the pure surfactant. However, best separations of enantiomers were obtained only in the presence of 10% v/v acetonitrile. Enantiomeric impurity in nonracemic mixtures of R‐ and S‐forms of BNP was determined.

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