Enantiomeric resolution of bifonazole by supercritical fluid chromatography

✍ Scribed by Laura Toribio; Ma Jesús del Nozal; José L. Bernal; Cristina Alonso; Juan J. Jiménez

• Book ID: 102926457
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 523 KB
• Volume: 29
• Category: Article
• ISSN: 1615-9306
• DOI: 10.1002/jssc.200600014

✦ Synopsis

Abstract

The enantiomeric separation of bifonazole by supercritical fluid chromatography on Chiralpak AD has been studied. The effect of different modifiers (methanol, ethanol, 2‐propanol, and acetonitrile) was examined. Enantioseparation was possible with all of them, but the best results were provided by the alcohol‐type ones. The resolution was higher than 5 in all cases. The isoelution temperatures T~iso~ were calculated from the study of the temperature effect for the different organic modifiers. The value of T~iso~ was below the working temperature range on using methanol, but above it with ethanol or 2‐propanol.