✦ LIBER ✦

Enantiomeric resolution of 1-[2-(3-hydroxyphenyl)-1-phenylethyl]-4- (3-methyl-2-butenyl)piperazine by reversed-phase high-performance liquid chromatography using a chiral mobile phase

✍ Scribed by Yoshifumi Nobuhara; Shiori Hirano; Yutaka Nakanishi

Publisher: Elsevier Science
Year: 1983
Tongue: English
Weight: 230 KB
Volume: 258
Category: Article
ISSN: 1873-3778
DOI: 10.1016/s0021-9673(00)96425-2

No coin nor oath required. For personal study only.

✦ Synopsis

A new analgesic, 1-[2-(3-hydroxyphenyl)-l-phenylethyl]-4-(3-methyl-2-butenyl)piperazine (Fig. l), has an asymmetric carbon in the molecule and it has been reported1 that the pharmacological activities of the R(-)-and S(+)-enantiomers were different. It is thus important to examine the optical purity of the enantiomers. P-CH2-CH - HO n P3 .

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