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Enantiomeric purity determination of propranolol by capillary electrophoresis using dual cyclodextrins and a polyacrylamide-coated capillary

✍ Scribed by Khaled A. Assi; Brian J. Clark; Kevin D. Altria

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
43 KB
Volume
20
Category
Article
ISSN
0173-0835

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✦ Synopsis

The use of a chirally selective capillary electrophoresis method is reported for the enantioselective purity determination of propranolol drug substance. The method employed a combination of both charged and neutral cyclodextrin. An internally coated capillary was used to suppress electroosmotic flow and potential peak tailing. The method was capable of monitoring below 0.1% m/m of the undesired impurity. Acceptable validation data was also obtained for recovery, linearity, and for both short and long-term injection precision.

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