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Enantiodivergent synthesis of both enantiomeric forms of substituted paraconic acids starting from d-mannitol as a chiral pool

✍ Scribed by Yukio Masaki; Hideki Arasaki; Akichika Itoh


Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
246 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis


Acetamide-acetal Clai~n rearrangement of the C2-symmetric enediol easily derived from D-mannitol provided a chiral C8-building block, which was demonstrated to be versatile for divergent synthesis of both enantiomeric forms of substituted paraconic acids.


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