## Abstract A short synthesis of __N__,1,2‐trisubstituted vicinal amino alcohols by 1,2‐addition of deprotonated __N__‐monosubstituted α‐amino nitriles to aldehydes and subsequent one‐pot reduction of the intermediates with borane–THF is described. This procedure leads to the predominant formation
Enantiodivergent Deprotonation/Acylation of α-Amino Nitriles
✍ Scribed by Sasaki, Michiko; Takegawa, Tomo; Sakamoto, Kunihiro; Kotomori, Yuri; Otani, Yuko; Ohwada, Tomohiko; Kawahata, Masatoshi; Yamaguchi, Kentaro; Takeda, Kei
- Book ID
- 121803588
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 394 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
## Michael addition / Nucleophilic acylation / Umpolung Investigations aimed at elucidating the structure of lithiated and by cryoscopic measurements of (S,S)-6 in THF. Trapping experiments complement the results. In THF, which constitu-α-amino nitriles B have led to the identification of N-lithio