Emulsion Electrospinning of a Collagen-Like Protein/PLGA Fibrous Scaffold: Empirical Modeling and Preliminary Release Assessment of Encapsulated Protein
✍ Scribed by Kai Wei; Yuan Li; Xiaowen Lei; Heejae Yang; Akira Teramoto; Juming Yao; Koji Abe; Frank K. Ko
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 929 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
The effectiveness of a multifunctional scaffold produced by the electrospinning of emulsions composed of organic PLGA and aqueous collagen‐like protein (denoted as Fol‐8Col) solutions is demonstrated. The resultant Fol‐8Col/PLGA fibrous scaffolds with homogeneous morphology have mean fiber diameters from 600 to 2 000 nm. A uniform distribution of encapsulated Fol‐8Col in the fibers is observed by fluorescence microscopy. TEM is used to clarify the representative core/sheath structure of emulsion electrospun Fol‐8Col/PLGA fibers. Preliminary release assessment of encapsulated Fol‐8Col shows results of sustained release for more than one month from the Fol‐8Col/PLGA fibrous mats. The cytocompatibility of fibroblast cell line L929 with the fibrous composite seems promosing. magnified image