Empirical genomewide significance levels established by whole genome simulations
✍ Scribed by Stephen Sawcer; Hywel B. Jones; David Judge; Frank Visser; Alastair Compston; Peter N. Goodfellow; David Clayton
- Book ID
- 101264385
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 43 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0741-0395
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✦ Synopsis
and markers used in our screen, an MLS of 3.2 carries a genome-wide significance of 5% (that is, there is a 5% probability of observing at least one false hit, above this threshold in a complete genome screen). This value is closer to the familiar limit of 3.0, originally suggested by Morton [1955; Am J Hum Genet 7:277-318] than to the more stringent limit of 4.0 recently proposed by Lander and Kruglyak [1995; Nat Genet 11:241-247]. This is somewhat reassuring, in view of the very large sample sizes that would be necessary to achieve adequate power to detect linkage at the more stringent threshold. Genet. Epidemiol. 14:223-229, 1997.