Empirical conformational energy study of the diastereomeric dipeptides MeCO-L-Ala-L-Ala-NHMe and MeCO-L-Ala-D-Ala-NHMe: an approach to the conformational analysis of stereocopolypeptides

(2S,5S,8S,11S)-1-Acetyl-1,4-diaza-3-keto

(2S,5S,8S,11S)-1-Acetyl-1,4-diaza-3-keto-5-carboxy-10-thia-tricyclo -[2.8.04,8]-tridecane, 1 the preferred conformation of 1 (1 ≡ αTemp-OH) and its peptide conjugates αTemp-L-(Ala)n-OR (n=1 to 4) and α-Temp-L-Ala-L-Phe-L-Lys(εBoc)-L-Lys(ε-Boc)-NHMe studies of templates for α-helix formation

✍ D.S. Kemp; Timothy P. Curran 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 281 KB

The conformation of the title compound 1 is deduced from 'H NMR evidence. The stable conformations of u-Temp-(L-Ala) NBMe in MeCN are shown to be distorte 8 -0tBu and a-Temp-L-Ala-L-Phe-L-Lys(cBoc)-L-Lys(&-Boc)ehelices with a bifurcated hydrogen bond. In the accompanying communication we have repor