## Abstract Genetic association studies are a powerful tool to detect genetic variants that predispose to human disease. Once an associated variant is identified, investigators are also interested in estimating the effect of the identified variant on disease risk. Estimates of the genetic effect ba
Empirical Bayes Correction for the Winner's Curse in Genetic Association Studies
β Scribed by John P. Ferguson; Judy H. Cho; Can Yang; Hongyu Zhao
- Book ID
- 115556041
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 714 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
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Quantitative traits (QT) are an important focus of human genetic studies both because of interest in the traits themselves and because of their role as risk factors for many human diseases. For large-scale QT association studies including genomewide association studies, investigators usually focus o
## Abstract Genomeβwide association studies (GWAS) provide an important approach for identifying common genetic variants that predispose to human disease. However, odds ratio (OR) estimates for the reported findings from GWAS discovery data are typically affected by a bias away from the null someti