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Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction

✍ Scribed by Tin-Yun Ho; Shih-Lu Wu; Jaw-Chyun Chen; Chia-Cheng Li; Chien-Yun Hsiang


Book ID
113457324
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
892 KB
Volume
74
Category
Article
ISSN
0166-3542

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Cholesterol present in the plasma membrane of target cells has been shown to be important for the infection by SARS-CoV. We show that cholesterol depletion by treatment with methyl-Ξ²-cyclodextrin (mΞ²CD) affects infection by SARS-CoV to the same extent as infection by vesicular stomatitis virus-bas