𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Emerging views of integrin signaling: Implications for prostate cancer

✍ Scribed by Jill K. Slack-Davis; J. Thomas Parsons

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
129 KB
Volume
91
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Integrins are heterodimeric transmembrane cellular receptors that link the cell to its underlying substratum. Alterations in integrin expression and signaling have been implicated in many aspects of tumorigenesis and metastasis including cell survival, migration, and invasion. In prostate cancer, the progression from normal to metastatic cells is accompanied by changes in the repertoire of integrins expressed and up‐regulation of key adhesion‐dependent signaling pathways. Recent work from several laboratories indicates the emergence of new mechanisms for the regulation of growth and migratory pathways by integrin engagement. These pathways are likely to provide novel sites of therapeutic intervention for the treatment of prostate cancer. © 2003 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Multifaceted interaction between the and
Multifaceted interaction between the androgen and Wnt signaling pathways and the implication for prostate cancer
✍ Stéphane Terry; Xuezhen Yang; Min-Wei Chen; Francis Vacherot; Ralph Buttyan 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB 👁 1 views

## Abstract Androgen action in prostate and prostate cancer cells is dependent upon the androgen receptor (AR) protein that transcriptionally regulates the expression of androgen‐dependent genes in the presence of a steroid ligand. Whereas the overall schema of androgen action mediated by this rece

Delta-aminolevulinic acid-mediated photo
Delta-aminolevulinic acid-mediated photosensitization of prostate cell lines: Implication for photodynamic therapy of prostate cancer
✍ Chakrabarti, Pradip; Orihuela, Eduardo; Egger, Norman; Neal, Durwood E.; Gangula 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 784 KB

BACKGROUND. Delta-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) is currently being investigated for the treatment of prostate diseases. In this study, we evaluate 1) the in vitro production of protoporphyrin IX (PPIX) (the active photosensitizing agent of ALA-mediated PDT) by two dif

Regulation of androgen receptor levels:
Regulation of androgen receptor levels: Implications for prostate cancer progression and therapy
✍ Kerry L. Burnstein 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB 👁 3 views

## Abstract Androgen deprivation has been the standard therapy for advanced and metastatic prostate cancer for over half a century, as prostate tumors are initially dependent on androgens for growth and survival. Unfortunately, in most patients undergoing androgen ablation, relapse (recurrent tumor