Emerging Trends in Cell and Gene Therapy

✍ Scribed by Russell Simpson, Qingbo Xu (auth.), Michael K. Danquah, Ram I. Mahato (eds.)

• Publisher: Humana Press
• Year: 2013
• Tongue: English
• Leaves: 712
• Edition: 1
• Category: Library

✦ Synopsis

Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies.Representing the combined effort of several leading international research and clinical experts, this book, Emerging Trends in Cell and Gene Therapy, provides a complete account on and brings into sharp focus current trends and state-of-the-art in important areas at the interface of cell- and gene-based therapies. This book addresses the current fragmented understanding regarding these two research areas and fills the vast unmet educational need and interest of both students and researchers in academia and industry.

Main features of the book:

· Biological aspects of stem cell sources, differentiation and engineering.

· Application of microfluidics to study stem cell dynamics

· Potential clinical application of stem cells and gene therapy to specific human disease.

· Utilization of biomaterials and stem cells in regenerative medicine with particular emphasis on spinal cord repair, ligament and bone tissue engineering.

· Biomimetic multiscale topography for cell alignment.

✦ Table of Contents

Front Matter....Pages i-xvii
The Mechanism of Stem Cell Differentiation into Smooth Muscle Cells....Pages 1-32
Recent Advances in Embryonic Stem Cell Engineering Toward Tailored Lineage Differentiation....Pages 33-54
Human Amniotic Membrane: A Potential Tissue and Cell Source for Cell Therapy and Regenerative Medicine....Pages 55-78
Novel Strategies Applied to Provide Multiple Sources of Stem Cells as a Regenerative Therapy for Parkinson’s Disease....Pages 79-95
Hair Follicle: A Novel Source of Stem Cells for Cell and Gene Therapy....Pages 97-118
Genetically Modified Stem Cells for Transplantation....Pages 119-146
Induced Pluripotent Stem Cells: Basics and the Application in Disease Model and Regenerative Medicine....Pages 147-168
Gene Transfer to the Heart: Emerging Strategies for the Selection of Vectors, Delivery Techniques, and Therapeutic Targets....Pages 169-206
Cell-Based Therapy for Cardiovascular Injury....Pages 207-224
Induced Pluripotent Stem Cells: New Advances in Cardiac Regenerative Medicine....Pages 225-249
Dendritic Cells for Cancer Immunotherapy....Pages 251-270
Mesenchymal Stem Cells: Prospects for Cancer Therapy....Pages 271-286
RNA Interference for Oncology: Clinical Prospects Beyond the Hype....Pages 287-305
Cell Therapy Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures....Pages 307-317
Stem Cell Therapies for the Treatment of Spinal Cord Injuries: Current Progress in Basic Science and Clinical Research....Pages 319-346
Pluripotent Stem Cells for Neural Regeneration....Pages 347-371
Synovial Mesenchymal Stem Cells and Their Applications in Musculoskeletal Regeneration....Pages 373-409
Stem Cell Therapy Aided Liver Regeneration....Pages 411-433
Application of Microfluidics to Study Stem Cell Dynamics....Pages 435-470
Biomimetic Multiscale Topography for Cell Alignment....Pages 471-483
Spinal Cord Repair by Means of Tissue Engineered Scaffolds....Pages 485-547
Stem Cells in Ligament Tissue Engineering....Pages 549-562
Biomaterials for Bone Tissue Engineering....Pages 563-594
Gene Therapy for the Inner Ear: Progress and Prospects....Pages 595-623
Preclinical Studies on Growth Plate Cartilage Regeneration Using Chondrocytes or Mesenchymal Stem Cells....Pages 625-636
Cell and Gene Transfer Strategies for Vascularization During Skin Wound Healing....Pages 637-695
Back Matter....Pages 697-705

✦ Subjects

Cell Biology; Gene Therapy; Biotechnology; Pharmaceutical Sciences/Technology