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Emerging roles of deubiquitinases in cancer-associated pathways

✍ Scribed by Joseph J. Sacco; Judy M. Coulson; Michael J. Clague; Sylvie Urbé

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
245 KB
Volume
62
Category
Article
ISSN
1521-6543

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✦ Synopsis

Abstract

Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c‐Myc. Alternatively they can negatively regulate ubiquitin‐dependent signalling cascades such as the NF‐κB activation pathway. We review the current literature that associates DUBs with cancer and discuss their suitability as drug targets of the future. © 2010 IUBMB IUBMB Life, 62(2): 140–157, 2010

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