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Emerging principles of de novo catalyst design

✍ Scribed by Lars Baltzer; Jonas Nilsson


Book ID
104361578
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
80 KB
Volume
12
Category
Article
ISSN
0958-1669

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πŸ“œ SIMILAR VOLUMES


De novo designed polypeptide catalysts w
✍ Lars Baltzer; Kerstin S. Broo πŸ“‚ Article πŸ“… 1998 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 187 KB

Designed polypeptide catalysts have been shown to catalyze hydrolysis and transesterification reactions of p-nitrophenyl esters by a mechanism that includes the nucleophilic attack by an unprotonated histidine and general-acid catalysis by a flanking protonated histidine. The catalysis is cooperativ