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Emergence of protein kinase CK2 as a key target in cancer therapy

โœ Scribed by Janeen H. Trembley; Zhong Chen; Gretchen Unger; Joel Slaton; Betsy T. Kren; Carter Van Waes; Khalil Ahmed

Book ID
112011119
Publisher
IOS Press
Year
2010
Tongue
English
Weight
299 KB
Volume
36
Category
Article
ISSN
0951-6433

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Protein kinase CK2 is a key activator of
Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors
โœ Sireerat Pluemsampant; Olga S. Safronova; Ken-ichi Nakahama; Ikuo Morita ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 751 KB

## Abstract Increasing evidence points to a link between histone deacetylases (HDACs) and tumorigenesis. Although several HDAC inhibitors have been tested in clinical trials for cancer therapies, the mechanisms of HDAC activation in tumors remain unknown. In this study, we investigated the pathway