Embryotoxicity of sixteen industrial amines to the chicken embryo

✍ Scribed by A. Korhonen; K. Hemminki; H. Vainio

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 385 KB
• Volume: 3
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550030210

✦ Synopsis

Sixteen amine compounds that are used in the rubber industry, and sodium nitrite, were tested on threeday chicken embryos for embryotoxicity. The parameters measured were: early deaths recorded within two days of injection, late deaths of malformed embryos, late deaths of non-malformed embryos and malformed survivors. The most embryotoxic chemicals were N-phenyl-N'-isopropyl-p-phenylenediamine, N,N,N-triethylethylenediamine, N,N'-dicyclohexyl-p-phenyleneamine and triethylamine, with total effect EDSo values, including deaths and malformations, between 0.11 and 0.90pmol per egg. The ED50 values for triethylenetetramine, N-( 1 ,3-dimethylbutyl)-Nf-phenyl-p-pheny1enediamine, triethanolamine, Nphenyl-2-naphtylamine, aniline and N-nitrosodiphenylamine ranged from 1.1 to 7.0 pmol per egg. Sodium nitrite was the least potent, with an EDso of 22pmol per egg. Six chemicals produced no effects. They probably did not reach the embryo. The four most potent chemicals, together with aniline, caused the highest frequencies of malformations.