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Embryopathic Effects of 7,12-Dimethylbenz(a)anthracene and its Hydroxymethyl Derivatives in the Sprague–Dawley Rat

✍ Scribed by CURRIE, A. R.; BIRD, C. C.; CRAWFORD, ALLISON M.; SIMS, P.


Book ID
109673695
Publisher
Nature Publishing Group
Year
1970
Tongue
English
Weight
487 KB
Volume
226
Category
Article
ISSN
0028-0836

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Treatment of female SpragueDawley rats with the potent mammary gland carcinogen 7,12dimethyC benz[a]anthracene (DMBA) results in the formation of DNA adducts with dG and dA and in the induction of 6thioguanineresistant (TG') lymphocyte mutants. In this study, we have examined the types of mutations