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Embryonic stem cell-derived precursors but not neurosphere cells efficiently differentiate to dopaminergic neurons in the embryonic midbrain

✍ Scribed by Jose Manuel Baizabal Carballo; Luis F. Covarrubias Robles


Book ID
116976533
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
48 KB
Volume
306
Category
Article
ISSN
0012-1606

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Parkinson's disease is characterized by the progressive degeneration of midbrain dopaminergic neurons. Several studies have examined the effects of the dopaminergic neurotrophins growth/differentiation factor 5 (GDF5) and glial cell line-derived neurotrophic factor (GDNF) on these neurons in vitro.