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Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

✍ Scribed by Niederreither, Karen; Subbarayan, Vemparala; Dollé, Pascal; Chambon, Pierre


Book ID
109828649
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
469 KB
Volume
21
Category
Article
ISSN
1061-4036

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## Abstract Vitamin A (VA) is required for normal fetal development and successful pregnancy. Excessive VA intake during pregnancy may lead to adverse maternal and fetal effects. Cytochrome P450 26A1 (cyp26a1), a retinoic acid (RA)‐metabolizing enzyme, is involved in VA metabolism. It has been show