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Embryonal rhabdomyosarcoma and chromosomal breakage in a newborn infant with possible Dubowitz syndrome

✍ Scribed by Al-Nemri, Abdul Rahman; Kilani, Ramzi A.; Salih, Mustafa A.M.; Al-Ajlan, Abdul Aziz

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
27 KB
Volume
92
Category
Article
ISSN
0148-7299

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✦ Synopsis

We report on a newborn girl with Dubowitz syndrome (DS) and embryonal rhabdomyosarcoma (ERMS), with multiple chromosomal breakage (MCB). The tumor was resected but recurred in a few months, resulting in the infant's death. Malignancy and chromosomal breakage have been reported previously in DS. However, ERMS has not been reported among the malignant tumors diagnosed in DS. To our knowledge, concurrence of DS, ERMS, and MCB has not been reported previously. This is the first observation of DS in the Arab ethnic group. Am.

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