Embryo-derived teratocarcinoma II. Teratocarcinogenesis depends on the type of embryonic graft
✍ Scribed by Davor Solter; Mara Dominis; Ivan Damjanov
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- French
- Weight
- 261 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Early post‐implantation mouse embryos or their embryonic and extraembryonic portions were transplanted under the kidney capsule of adult isogenic recipients in order to test the tumor‐producing potential of various grafts and to establish the optimal conditions for teratocarcinoma production. The highest yield of malignant tumors was obtained from 7‐day embryos transplanted in toto. Severing the extraembryonic portion of 7‐day egg cylinders prior to transplantation of the embryonic part reduced the number of teratocarcinomas to values comparable with those obtained from transplanted 6‐day embryos. The extraembryonic portion of 7‐day embryos produced no tumors. These data suggest that extraembryonic portions of the 7‐day egg cylinder do not have tumorigenic potential alone, but may increase the yield of teratocarcinomas from the embryonic portion of the egg cylinder.