Elucidation of enzyme control mechanisms using macroscopic measurements in a mixed substrate fermentation system

Real-time monitoring of protein secretio

Real-time monitoring of protein secretion in mammalian cell fermentation: Measurement of monoclonal antibodies using a computer-controlled HPLC system (BioCad/RPM)

✍ S. S. Ozturk; J. C. Thrift; J. D. Blackie; D. Naveh 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 559 KB

On-line, "real-time" monitoring of product concentration is important for mammalian cell culture fermentation. The continuous measurement of monoclonal antibodies allows for instantaneous determination of cell productivity and effective manipulation of the fermentor operating conditions for optimal