Ellipsometry studies of the mucoadhesion of cellulose derivatives

✍ Scribed by Martin Malmsten; Ingela Ljusegren; Ingemar Carlstedt

• Book ID: 103967678
• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 735 KB
• Volume: 2
• Category: Article
• ISSN: 0927-7765
• DOI: 10.1016/0927-7765(94)80054-5

✦ Synopsis

The mucoadhesion of three different cellulose derivatives. ethyl( hydroxyethyl)cellulose (EHEC), hydrophobically modified hydroxyethyl cellulose (h-HEC) and a cationic cellulose derivative (ammo cellulose), was investigated by in situ elhpsometry.

In the measurements. gastric mucm from rat was first adsorbed onto hydrophobtzed silica. which provided good anchorage for the mucm layer and allowed a large amount of mucin to be adsorbed. Sigmficant mucoadhesion was obtained for all three cellulose derivatives, mdicatmg that overall solvency effects, electrostatic interactions or hydrophobic groups may be used to obtam mucoadhesion m cellulose systems. Of the polymers used, EHEC showed the greatest adsorption tendency which may indicate that the first approach is preferable for obtaining efficient mucoadhesion.

The addition of sodium dodecyl sulphate (SDS) was found to counteract the mucoadhesion of EHEC