Different epitopes on the extracellular domain of the HER-2 receptor can serve as distinct targets for immunotoxins. To determine the optimal epitope target for immunotoxin therapy, 7 anti-HER-2 ricin A chain murine monoclonal immunotoxins, each reactive with different epitopes of HER-2 receptor, we
β¦ LIBER β¦
ELISA for quantitation of the extracellular domain of p185HER2 in biological fluids
β Scribed by Patricia E. Sias; Claire E. Kotts; David Vetterlein; Mike Shepard; Wai Lee T. Wong
- Book ID
- 118902052
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 568 KB
- Volume
- 132
- Category
- Article
- ISSN
- 0022-1759
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## Abstract Overβexpression of the cβ__erb__Bβ2 (HERβ2/__neu__) gene product p185 occurs in 30% of breast and ovarian cancers. The p185 protein might serve as a target for serotherapy in that antibodies against different epitopes on the extracellular domain of p185 can inhibit growth of tumor cells
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