Elimination of the Class A Scavenger Receptor Does Not Affect Amyloid Plaque Formation or Neurodegeneration in Transgenic Mice Expressing Human Amyloid Protein Precursors

Twofold overexpression of human ?-amyloi

Twofold overexpression of human ?-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury

✍ Murai, Hisayuki; Pierce, Jean E.S.; Raghupathi, Ramesh; Smith, Douglas H.; Saatm 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 270 KB 👁 2 views

By using transgenic mice that overexpress human beta-amyloid precursor proteins (APPs) at levels twofold higher than endogenous APPs, following introduction of the human APP gene in a yeast artificial chromosome (YAC), we examined the effects of controlled cortical impact (CCI) brain injury on neuro