active TGF-b in MFBcM as mediator of the apoptotic The induction of apoptosis of rat liver parenchymal effects of MFB was proven by preincubation of the condicells (PC) by transforming growth factor b (TGF-b)-extioned medium with human recombinant latency-associpressing transformed fat-storing cells
Elimination of preneoplastic rat liver cells via induction of apoptosis by transforming growth factor β1
✍ Scribed by B. Grasl-Kraupp; L. Müllauer; B. Ruttkay-Nedecky; W. Bursch; R. Schulte-Hermann
- Book ID
- 112784553
- Publisher
- Springer-Verlag
- Year
- 1995
- Tongue
- English
- Weight
- 141 KB
- Volume
- 121
- Category
- Article
- ISSN
- 1432-1335
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In previous work we showed that interferon alfa-2b (IFN-alpha2b) increases apoptosis on rat hepatic preneoplastic foci. The aim of this study was to determine if transforming growth factor beta1 (TGF-beta1) was involved in the programmed cell death on the foci. Animals were divided into 6 groups: su
Transforming growth factor β 1 (TGF-β 1 ) has been implicated as inhibitor of cell proliferation and a potent inducer of apoptosis in vitro and in vivo after the administration of high doses. To assess the role of endogenous TGF-β 1 , we quantitated the cytokine and its receptors in rat liver during