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Elimination of a Misfolded Folding Intermediate by a Single Point Mutation

✍ Scribed by Mogensen, Jesper E.; Ipsen, Henrik; Holm, Jens; Otzen, Daniel E.


Book ID
127346828
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
265 KB
Volume
43
Category
Article
ISSN
0006-2960

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πŸ“œ SIMILAR VOLUMES


Cis proline mutants of ribonuclease A. I
✍ David A. Schultz; Robert L. Baldwin; Franz X. Schmid πŸ“‚ Article πŸ“… 1992 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 729 KB

## Abstract Ribonuclease A is known to form an equilibrium mixture of fast‐folding (U~F~) and slow‐folding (U~S~) species. Rapid unfolding to U~F~ is then followed by a reaction in the unfolded state, which produces a mixture of U~F~, U~S~II, U~S~I, and possibly also minor populations of other U~S~