## Abstract ## Objective Randomized clinical trials (RCTs) evaluate the efficacy of treatments in selected groups of patients defined by strict inclusion criteria. The value of these trials in predicting therapeutic effectiveness in “real world” patients is limited. This observational cohort study
Eligibility of patients in routine care for major clinical trials of anti–tumor necrosis factor α agents in rheumatoid arthritis
✍ Scribed by Tuulikki Sokka; Theodore Pincus
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 73 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To assess the association between the initiation of anti–tumor necrosis factor α (anti‐TNFα) therapy and the risk of serious bacterial infections in routine care. ## Methods This was a cohort study of patients with rheumatoid arthritis (RA) in whom specific disease‐modif
## Abstract ## Objective Patients with rheumatoid arthritis (RA) in whom the response to anti–tumor necrosis factor (anti‐TNF) therapy is inadequate have several therapeutic options, such as switching to an alternative anti‐TNF agent or initiating B cell–depleting therapy with rituximab (RTX). Alt
## Abstract ## Objective Limited data have been published on tolerance to and efficacy of classic or biologic disease‐modifying antirheumatic drugs in elderly patients with rheumatoid arthritis (RA). The goal of the present study was to evaluate the tolerance to and effectiveness of anti–tumor nec