Elevation of soluble interleukin-2 receptor levels in the bronchoalveolar lavage from patients with systemic sclerosis
✍ Scribed by José Martinez; Cinthya Nishimura; Sandra Guatura; Emilia Sato; Talmadge E. King
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 86 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0172-8172
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📜 SIMILAR VOLUMES
## Abstract ## Objective To examine the expression and regulation of interleukin‐21 (IL‐21) and IL‐21 receptor (IL‐21R) in patients with systemic sclerosis (SSc; scleroderma). ## Methods Skin biopsy specimens were obtained from 23 patients with SSc and 15 healthy controls. IL‐21/IL‐21R messenger
In a previous study, we used an enzyme-linked immunosorbent assay to measure soluble human interleukin-2 receptors (IL3R), and found that when activated lymphocytes produce cell-associated IL-2R, they also release a soluble form of IL3R into culture supernatants in vitro. Soluble IL-2R have also bee