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Elevation of serum type IV collagen-degrading enzyme in hepatocellular carcinoma with metastasis

✍ Scribed by Y. Kimura; N. Hashimoto; M. Kobayashi; T. Higashi; A. Watanabe; T. Tsuji

Book ID
103039144
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
449 KB
Volume
23
Category
Article
ISSN
0009-9120

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✦ Synopsis

The activity of serum type IV collagen-degrading enzyme was measured in 21 patients with hepatocellular carcinoma, and the changes in the enzyme activity were investigated with respect to metastasis. The activity of serum type IV collagen-degrading enzyme did not increase until tumor invasion to the portal vein and intrahepatic metastasis were clearly detected ultrasonographically. Activities did not increase during the observation period in patients whose tumor grew slowly and did not invade the portal vein. Thus, the enzyme activity increases in relation to the metastasis of hepatocellular carcinoma and may be useful to detect ongoing metastases.

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✍ Debayo M. Bolarin; Eeva-Riitta Savolainen; Kari I. Kivirikko πŸ“‚ Article πŸ“… 1982 πŸ› John Wiley and Sons 🌐 French βš– 492 KB

## Abstract Serum immunoreactive prolyl hydroxylase protein (S‐IRPH), galactosylhydroxylysyl glucosyltransferase activity (S‐GGT) and the amino‐terminal propeptide of type III procollagen [S‐Pro(III)‐N‐P] were studied in 24 patients with primary hepatocellular carcinoma, 18 with secondary liver neo