Elevation of glutathione and γ-glutamyl cycle enzyme activities and mRNA by naphthoquinones
✍ Scribed by Henry Jay Forman; Ming Shi; Amir Kugelman; Henry A. Choy
- Book ID
- 113386246
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 164 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0891-5849
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The first and rate-limiting reaction in the formation of glutathione is catalyzed by ␥-glutamylcysteine synthetase (GCS), a dimer composed of a catalytic heavy and a regulatory light subunit. We previously found that heavy subunit GCS mRNA appears to be expressed at high levels in the hippocampus, c
The unprecedented ability of cyclosporin A, when given for six days at a dose of 25 mg/kg/d or 50 mg/kg/d, to cause a marked and sustained increase in renal glutathione (GSH) concentration in rat kidney is described. This response was particular to the kidney insofar as the GSH concentration in the