Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma

Expression of Smad4 in the FaDu cell lin

Expression of Smad4 in the FaDu cell line partially restores TGF-beta growth inhibition but is not sufficient to regulate fibronectin expression or suppress tumorigenicity

✍ B. Timothy Hummer; Christopher Bartlett; Erin Henry; Bernard E. Weissman 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 354 KB

## Abstract Mutations of the Smad4 gene, a member of a group of TGF‐β signal transduction components, occur in several types of cancer suggesting that its inactivation significantly affects TGF‐β responsiveness in these tumors. To further investigate the role of Smad4 with respect to TGF‐β signalin