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Elevation of cyclic amp in C-1300 murine neuroblastoma by adenosine and related compounds and the antagonism of this response by methylxanthines

✍ Scribed by Richard D. Green; Lawrence R. Stanberry


Book ID
115773436
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
879 KB
Volume
26
Category
Article
ISSN
0006-2952

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Activation of cyclic AMP-dependent prote
✍ Green, Richard D. ;Noland, Thomas A. πŸ“‚ Article πŸ“… 1979 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 590 KB

DEAE-cellulose chromatography of the 20,000g supernatant fraction of homogenates of C-1300 murine neuroblastoma (clone N2a) yields one major and two minor peaks of cyclic AMP-dependent protein kinase activity. Assessment of the endogenous activation state of the enzyme(s) reveals that the enzyme is