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Elevated serum levels of transforming growth factor-α in breast cancer patients

✍ Scribed by Chakrabarty, Subhas; Huang, Shuang; Moskal, Thomas L.; Fritsche, Herbert A.


Book ID
123129838
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
359 KB
Volume
79
Category
Article
ISSN
0304-3835

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Nasopharyngeal carcinomas (NPCs) of non-keratinizing type are strongly associated with Epstein-Barr virus (EBV). EBV and its gene products induce the synthesis and/or release of transforming growth factor ␤1 (TGF-␤1) from human cells and platelets. TGF-␤1 is an immunosuppressive cytokine, and many t