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Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

✍ Scribed by David S Cassarino; Christopher P Fall; Russell H Swerdlow; Trisha S Smith; Erik M Halvorsen; Scott W Miller; Janice P Parks; W.Davis Parker Jr.; James P Bennett Jr.


Book ID
117618258
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
238 KB
Volume
1362
Category
Article
ISSN
0925-4439

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## Abstract Machado‐Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by polyglutamine expansion in the ataxin‐3 protein that confers a toxic gain of function. Because of the late onset of the disease, we hypothesize that the accumu