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Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer

✍ Scribed by Lin, H-J; Hsieh, F-C; Song, H; Lin, J

Book ID
118123498
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
242 KB
Volume
93
Category
Article
ISSN
0007-0920

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## Abstract Akt signaling may promote breast cancer progression and poor disease outcome. We hypothesized that serum insulin‐like growth factor I (IGF‐I) and a proinflammatory tumor environment induce phosphorylation of Akt and downstream targets of Akt in breast cancer. We studied the relationship